Three years after the disappearance of 2% of the global population, a group of people from New York struggle to continue their lives, while they cope with the tragedy of the unexplained nature of the event.

Two strangers are drawn to a mysterious pharmaceutical trial that will, they're assured, with no complications or side-effects whatsoever, solve all of their problems, permanently. Things do not go as planned.

Allie Fox—a brilliant inventor and stubborn idealist—uproots his family for a dangerous quest through Mexico to flee the U.S. government and find safety.